Article

Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion from Human Islets

2024-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Adipose triglyceride lipase (ATGL), which catalyzes the breakdown of triglycerides in lipid droplets (LDs), plays a critical role in releasing fatty acids to support insulin secretion in pancreatic beta cells. Based on genetic downregulation of ATGL in beta cells, multiple mechanisms are proposed that acutely or chronically regulate insulin secretion. Currently, the contribution of acute versus...

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Literature Corpus work: 07f85733-e16d-5b23-ab25-44d82c7139b6
DOI: 10.1101/2024.11.11.623085

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Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion from Human IsletsDOI 10.1101/2024.11.11.623085Read

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