Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development.

The EMBO journal - 1 Aug 2003

Weng Li, Zhu Chenwen, Xu Jinhua, Du Wei

Abstract excerpt

E2F transcription factors can activate or actively repress transcription of their target genes. The role of active repression during normal development has not been analyzed in detail. dE2F1(su89) is a novel allele of dE2F1 that disrupts dE2F1's association with RBF [the Drosophila retinoblastoma protein (Rb) homolog] but retains its transcription activation function. Interestingly, the dE2F1(su89) mutant, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to DNA-Binding Proteins
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to E2F Transcription Factors

Share to Fertility

Share to Genes, Lethal

Share to Microscopy, Electron, Scanning

Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 12881421
DOI: 10.1093/emboj/cdg373
PMCID: PMC169046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development.PMID 12881421Read ↗

Alternate transcripts of the Drosophila "activator" E2F are necessary for maintenance of cell cycle exit during development.Semantic proximity Read ↗

Functional antagonism between E2F family members.Semantic proximity Read ↗

Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain.Semantic proximity Read ↗

dDP is needed for normal cell proliferation.Semantic proximity Read ↗

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.Semantic proximity Read ↗

A Cyclin A—Myb-MuvB—Aurora B network regulates the choice between mitotic cycles and polyploid endoreplication cyclesSemantic proximity Read ↗

Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis.Semantic proximity Read ↗

A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesis.Semantic proximity Read ↗

S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.Semantic proximity Read ↗

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.Semantic proximity Read ↗

Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program.Semantic proximity Read ↗

The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.