Article
Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.
Genes & development - 1 Jun 1995
Sauer K, Knoblich J A, Richardson H, Lehner C F
Abstract excerpt
Drosophila cyclin E (DmcycE) is required in embryos for S phase of mitotic and endoreduplication cycles. Here, we describe regulatory differences characteristic for these two cell cycle types. While DmcycE transcript levels decline in DmcycE mutant cells programmed for mitotic proliferation, they are maintained and no longer restricted to transient pulses in DmcycE mutant cells programmed for endoreduplication....
Topics
- Animals
- Cell Cycle
- Cyclins
- Drosophila
- Gene Expression Regulation, Developmental
- Mutation
- Protein Kinases