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Article

S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.

PLoS genetics - 1 Jan 2012

Davidson Jean M, Duronio Robert J

Abstract excerpt

Precise control of cell cycle regulators is critical for normal development and tissue homeostasis. E2F transcription factors are activated during G1 to drive the G1-S transition and are then inhibited during S phase by a variety of mechanisms. Here, we genetically manipulate the single Drosophila activator E2F (E2f1) to explore the developmental requirement for S phase-coupled E2F down-regulation. Expression of...

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Identifiers

PMID: 22916021
DOI: 10.1371/journal.pgen.1002831
PMCID: PMC3420931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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