Article
Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program.
Genes & development - 1 Aug 1997
Royzman I, Whittaker A J, Orr-Weaver T L
Abstract excerpt
The E2F transcription factor, a heterodimer of E2F and DP subunits, is capable of driving the G1-S transition of the cell cycle. However, mice in which the E2F-1 gene had been disrupted developed tumors, suggesting a negative role for E2F in controlling cell proliferation in some tissues. The consequences of disrupting the DP genes have not been reported. We screened for mutations that disrupt G1-S transcription...
Topics
- Amino Acid Sequence
- Animals
- Carrier Proteins
- Cell Cycle Proteins
- Cyclins
- DNA Replication
- DNA-Binding Proteins
- Dimerization
- Drosophila
- Drosophila Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Eye
- Female