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Article

Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program.

Genes & development - 1 Aug 1997

Royzman I, Whittaker A J, Orr-Weaver T L

Abstract excerpt

The E2F transcription factor, a heterodimer of E2F and DP subunits, is capable of driving the G1-S transition of the cell cycle. However, mice in which the E2F-1 gene had been disrupted developed tumors, suggesting a negative role for E2F in controlling cell proliferation in some tissues. The consequences of disrupting the DP genes have not been reported. We screened for mutations that disrupt G1-S transcription...

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Identifiers

PMID: 9271122
DOI: 10.1101/gad.11.15.1999
PMCID: PMC316409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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