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Article

Alternate transcripts of the Drosophila "activator" E2F are necessary for maintenance of cell cycle exit during development.

Developmental biology - 15 Mar 2016

Bradley-Gill Mary-Rose, Kim Minhee, Feingold Daniel, Yergeau Christine, Houde Josée, Moon Nam-Sung

Abstract excerpt

The E2F family of transcription factors are evolutionarily conserved regulators of the cell cycle that can be divided into two groups based on their ability to either activate or repress transcription. In Drosophila, there is only one "activator" E2F, dE2F1, which provides all of the pro-proliferative activity of E2F during development. Interestingly, the de2f1 gene can be transcribed from multiple promoters...

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PMID: 26859702
DOI: 10.1016/j.ydbio.2016.02.004

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