High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment

Abstract excerpt

The recent report by Tobin et al[1][1] that chronic lymphocytic leukemia (CLL) patients using the VH3-21 gene segment have a poor prognosis despite mostly having more than 2% VH mutation has generated a considerable amount of interest.[2][2]-[4][3] This is partly because such cases constitute an

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