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Article

Distinctive gene expression pattern in VH3-21 utilizing B-cell chronic lymphocytic leukemia.

Blood - 15 Jul 2005

Fält Susann, Merup Mats, Tobin Gerard, Thunberg Ulf, Gahrton Gösta, Rosenquist Richard, Wennborg Anders

Abstract excerpt

The usage of the immunoglobulin (Ig) V(H)3-21 gene is associated with poor prognosis in B-cell chronic lymphocytic leukemia (B-CLL) despite V(H) gene mutation status. Many V(H)3-21+ patients also display restricted heavy- and light-chain Ig gene rearrangements, implying a role of antigen selection in disease development. To explore the specific phenotypic/genotypic features among V(H)3-21+ B-CLLs, we compared...

Read the complete abstract on PubMed

Topics

Aged
Aged, 80 and over
Algorithms
Cell Cycle
Female
Gene Expression Profiling
Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

Humans

Leukemia, Lymphocytic, Chronic, B-Cell

Male

Middle Aged

Oligonucleotide Array Sequence Analysis

Phenotype

Prognosis

Receptors, Antigen, B-Cell

Signal Transduction

Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 15817677
DOI: 10.1182/blood-2004-10-4073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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