Article
[Immunoglobulin variable heavy chain region genetic constitution and mutation status in Chinese patients with chronic lymphocytic leukemia].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Apr 2009
Zhang Ya-ping, Chen Li-juan, Xu Wei, Qiao Chun, Qian Si-xuan, Qiu Hong-xia, Miao Kou-rong, Liu Hong, Li Jian-yong
Abstract excerpt
OBJECTIVE: To evaluate the genetic constitution and mutation status of the immunoglobulin variable heavy chain region (IGVH) gene expression in Chinese patients with chronic lymphocytic leukemia (CLL). METHODS: The IGVH mutation was detected by multiplex PCR and direct sequencing of the purified PCR products from 64 CLL patients. The segments of VH, DH and JH family and mutations were analyzed by IMGT/V-QUEST and...
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