Article
V(H)3-21 gene usage in chronic lymphocytic leukemia--characterization of a new subgroup with distinct molecular features and poor survival.
Leukemia & lymphoma - 1 Feb 2004
Tobin Gerard, Söderberg Ola, Thunberg Ulf, Rosenquist Richard
Abstract excerpt
During recent years it has become evident that lymphoproliferative diseases of B-cell origin display preferential immunoglobulin (Ig) variable heavy chain (V(H)) gene usage. For instance, the V(H)1-69 and V(H)4-34 genes were early found to be overexpressed in B-cell chronic lymphocytic leukemia (CLL) and other B-cell lymphomas. The implications of biased V(H) gene usage have been speculated to be a result of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
