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Article

Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia.

Blood - 15 Mar 2002

Tobin Gerard, Thunberg Ulf, Johnson Anna, Thörn Ingrid, Söderberg Ola, Hultdin Magnus, Botling Johan, Enblad Gunilla, Sällström Jan, Sundström Christer, Roos Göran, Rosenquist Richard

Abstract excerpt

Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases and correlated them to overall survival. A novel finding was the preferential use of the...

Topics

Aged
Complementarity Determining Regions
Female
Genes, Immunoglobulin
Genetic Testing
Genotype
Humans
Immunoglobulin lambda-Chains
Leukemia, Lymphocytic, Chronic, B-Cell
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Survival Rate

Source

Identifiers

PMID: 11877310
DOI: 10.1182/blood.v99.6.2262

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Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia.PMID 11877310Read ↗

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