[Overrepresentation of specific gene segments of expressed immunoglobulin heavy chain variable region among unmutated and mutated patients with chronic lymphocytic leukemia].

Abstract excerpt

OBJECTIVE: To investigate the overrepresentation of specific gene segments of immunoglobulin heavy chain variable region (IgVH) among unmutated and mutated chronic lymphocytic leukemia (CLL) patients and its prognostic implication. METHODS: Multiplex PCR was used to identify the expression of IgVH segment and its mutation status in CLL. RESULTS: Analyses were successfully performed in 80 of 85 samples. Marked...

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