Article
Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells.
Molecular biology of the cell - 1 Jul 2003
Turowski Patric, Franckhauser Celine, Morris May C, Vaglio Philippe, Fernandez Anne, Lamb Ned J C
Abstract excerpt
In view of the common regulatory mechanism that induces transcription of the mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit. Here, we show that in both nontransformed human fibroblasts and HeLa cells, cdc25C protein levels significantly increased concomitant with S-phase onset and cyclin A synthesis. Activity measurements on...
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