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Article

A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.

Molecular biology of the cell - 1 Apr 2006

Margolis Seth S, Perry Jennifer A, Weitzel Douglas H, Freel Christopher D, Yoshida Minoru, Haystead Timothy A, Kornbluth Sally

Abstract excerpt

The Cdc25 phosphatase promotes entry into mitosis through the removal of inhibitory phosphorylations on the Cdc2 subunit of the Cdc2/CyclinB complex. During interphase, or after DNA damage, Cdc25 is suppressed by phosphorylation at Ser287 (Xenopus numbering; Ser216 of human Cdc25C) and subsequent binding of the small acidic protein, 14-3-3. As reported recently, at the time of mitotic entry, 14-3-3 protein is...

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Identifiers

PMID: 16467385
DOI: 10.1091/mbc.e05-08-0751
PMCID: PMC1415323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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