Article

Cyclin A2/Cdk1 is Essential for the <i>in vivo</i> S Phase Entry by Phosphorylating Top2a

2019-01-07

Abstract excerpt

Cyclin-dependent kinase 1 (CDK1) plays essential roles in cell cycle regulation. However, due to the early embryonic lethality of mouse Cdk1 mutants, the in vivo role of CDK1 in regulating cell cycle and embryonic development remains unclear. Here, by generating zebrafish cdk1 mutants using CRISPR/Cas9 system, we show that cdk1 −/− embryos exhibit severe microphthalmia accompanied with multiple defects in pola...

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Literature Corpus work: 7aa90426-472d-5760-a60f-4d3e1bccadb3
DOI: 10.1101/513861

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