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Article

S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase.

Oncogene - 20 Jun 1996

Spitkovsky D, Jansen-Dürr P, Karsenti E, Hoffman I

Abstract excerpt

Adenovirus E1A proteins can induce quiescent cells to enter S-phase and also affect the expression of cellular genes including various cell cycle regulators. Here we show that human cdc25A, a tyrosine phosphatase involved in regulation of the G1/S-phase transition of the cell cycle, is a target of the adenovirus E1A protein in virus-infected human fibroblasts. Expression of E1A in quiescent fibroblasts leads to a...

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Source

Identifiers

PMID: 8700513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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