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Article

Phosphorylation of CDC25A on SER283 in late S/G2 by CDK/cyclin complexes accelerates mitotic entry.

Cell cycle (Georgetown, Tex.) - 17 Oct 2016

Mazzolini Laurent, Broban Anaïs, Froment Carine, Burlet-Schiltz Odile, Besson Arnaud, Manenti Stéphane, Dozier Christine

Abstract excerpt

The Cdc25A phosphatase is an essential activator of CDK-cyclin complexes at all steps of the eukaryotic cell cycle. The activity of Cdc25A is itself regulated in part by positive and negative feedback regulatory loops performed by its CDK-cyclin substrates that occur in G1 as well as during the G1/S and G2/M transitions. However, the regulation of Cdc25A during G2 phase progression before mitotic entry has not...

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Identifiers

PMID: 27580187
DOI: 10.1080/15384101.2016.1220455
PMCID: PMC5053558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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