Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis.

doi:10.1083/jcb.146.3.573

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Article

Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis.

The Journal of cell biology - 9 Aug 1999

Karlsson C, Katich S, Hagting A, Hoffmann I, Pines J

Abstract excerpt

We have used time-lapse fluorescence microscopy to study the properties of the Cdc25B and Cdc25C phosphatases that have both been implicated as initiators of mitosis in human cells. To differentiate between the functions of the two proteins, we have microinjected expression constructs encoding Cdc25B or Cdc25C or their GFP-chimeras into synchronized tissue culture cells. This assay allows us to express the...

Topics

Biological Transport
CDC2 Protein Kinase
Cell Cycle Proteins
Cell Nucleus
Chromosomes
Cyclin B
Cyclin B1
Cytoplasm
DNA
Dose-Response Relationship, Drug
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Humans

Interphase

Microinjections

Microscopy, Fluorescence

Mitosis

Mutation

Source

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Identifiers

PMID: 10444066
DOI: 10.1083/jcb.146.3.573
PMCID: PMC2150562

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