Placentation defects are highly prevalent in embryonic lethal mouse mutants.

doi:10.1038/nature26002

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Article

Placentation defects are highly prevalent in embryonic lethal mouse mutants.

Nature - 22 Mar 2018

Perez-Garcia Vicente, Fineberg Elena, Wilson Robert, Murray Alexander, Mazzeo Cecilia Icoresi, Tudor Catherine, Sienerth Arnold, White Jacqueline K, Tuck Elizabeth, Ryder Edward J, Gleeson Diane, Siragher Emma, Wardle-Jones Hannah, Staudt Nicole, Wali Neha, Collins John, Geyer Stefan, Busch-Nentwich Elisabeth M, Galli Antonella, Smith James C, Robertson Elizabeth, Adams David J, Weninger Wolfgang J, Mohun Timothy, Hemberger Myriam

Abstract excerpt

Large-scale phenotyping efforts have demonstrated that approximately 25-30% of mouse gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused on the embryo and not the placenta, despite the crucial role of this extraembryonic organ for developmental progression. Here we screened 103 embryonic lethal and sub-viable mouse knockout lines from the Deciphering the Mechanisms of...

Topics

Animals
Embryo Loss
Female
Mice
Mice, Knockout
Mutation
Placenta
Placentation
Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stem Cells

Trophoblasts

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Identifiers

PMID: 29539633
DOI: 10.1038/nature26002
PMCID: PMC5866719

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