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Article

Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development.

Biochemistry. Biokhimiia - 1 Jan 2002

Aasrum M, Prydz Hans

Abstract excerpt

Inactivation of specific genes in mammals by gene targeting has accelerated our ability to determine gene function. Nearly all genes involved in the blood coagulation system have been knocked out in mice. Tissue factor (TF) is the main initiator of the coagulation system and functions as a cell surface receptor for coagulation factor VII (FVII). Knockout studies have shown that TF deficiency results in lethality...

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Identifiers

PMID: 11841337
DOI: 10.1023/a:1013943912668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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