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Article

Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers

16 Apr 2007

Abstract excerpt

We describe a mouse model of fetal loss in factor V Leiden (FvL) mothers in which fetal loss is triggered when the maternal prothrombotic state coincides with fetal gene defects that reduce activation of the protein C anticoagulant pathway within the placenta. Fetal loss is caused by disruption of placental morphogenesis at the stage of labyrinth layer formation and occurs in the absence of overt placental...

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Share to Blood Coagulation and Thrombosis Mechanisms
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Identifiers

PMID: 17438064
DOI: 10.1084/jem.20062566

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