Article
ROCK-I and ROCK-II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 2005
Thumkeo Dean, Shimizu Yoshihiko, Sakamoto Satoko, Yamada Shuichi, Narumiya Shuh
Abstract excerpt
Rho-associated kinase (ROCK) is a serine/threonine kinase working in the Rho signaling to actin cytoskeleton. We previously reported that loss of ROCK-I results in the eyelid open at birth (EOB) and omphalocele phenotype in mice, while loss of ROCK-II results in placental dysfunction leading to intrauterine growth retardation and fetal death. Here, we report that after backcross to the C57BL/6 N genetic...
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