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Article

Essential role of the ERK/MAPK pathway in blood-placental barrier formation.

Development (Cambridge, England) - 1 Jul 2014

Nadeau Valérie, Charron Jean

Abstract excerpt

The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and Map2k2, which encode dual-specificity kinases responsible for ERK activation. Loss of Map2k1 function in mouse causes embryonic lethality due to placental defects, whereas Map2k2 mutants have a normal lifespan. The majority of Map2k1(+/-) Map2k2(+/-) embryos die during gestation from the underdevelopment of the placenta labyrinth,...

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PMID: 24948605
DOI: 10.1242/dev.107409

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