Article
Advantage of rare HLA supertype in HIV disease progression.
Nature medicine - 1 Jul 2003
Trachtenberg Elizabeth, Korber Bette, Sollars Cristina, Kepler Thomas B, Hraber Peter T, Hayes Elizabeth, Funkhouser Robert, Fugate Michael, Theiler James, Hsu Yen S, Kunstman Kevin, Wu Samuel, Phair John, Erlich Henry, Wolinsky Steven
Abstract excerpt
The highly polymorphic human leukocyte antigen (HLA) class I molecules help to determine the specificity and repertoire of the immune response. The great diversity of these antigen-binding molecules confers differential advantages in responding to pathogens, but presents a major obstacle to distinguishing HLA allele-specific effects. HLA class I supertypes provide a functional classification for the many...
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