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Article

Human leukocyte antigen class I supertypes and HIV-1 control in African Americans.

Journal of virology - 1 Mar 2010

Lazaryan Aleksandr, Song Wei, Lobashevsky Elena, Tang Jianming, Shrestha Sadeep, Zhang Kui, Gardner Lytt I, McNicholl Janet M, Wilson Craig M, Klein Robert S, Rompalo Anne, Mayer Kenneth, Sobel Jack, Kaslow Richard A

Abstract excerpt

The role of human leukocyte antigen (HLA) class I supertypes in controlling human immunodeficiency virus type 1 (HIV-1) infection in African Americans has not been established. We examined the effects of the HLA-A and HLA-B alleles and supertypes on the outcomes of HIV-1 clade B infection among 338 African American women and adolescents. HLA-B58 and -B62 supertypes (B58s and B62s) were associated with favorable...

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Identifiers

PMID: 20032191
DOI: 10.1128/JVI.01962-09
PMCID: PMC2820922

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