Article
Human leucocyte antigen supertypes and immune susceptibility to HIV-1, implications for vaccine design.
Immunology letters - 1 Nov 2001
MacDonald K S, Matukas L, Embree J E, Fowke K, Kimani J, Nagelkerke N J, Oyugi J, Kiama P, Kaul R, Luscher M A, Rowland-Jones S, Ndinya-Achola J, Ngugi E, Bwayo J J, Plummer F A
Abstract excerpt
T cell responses against HIV-1 have been identified in a number of exposed uninfected populations. We hypothesized that the ability to mount an effective T cell response is partly determined by the human leucocyte antigens (HLA) phenotype of the individual. We examined whether certain HLA supertypes were associated with differential HIV-1 susceptibility in sexually exposed adults and in the setting of mother to...
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