Article
Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2006
Leslie Alasdair, Price David A, Mkhize Pamela, Bishop Karen, Rathod Almas, Day Cheryl, Crawford Hayley, Honeyborne Isobella, Asher Tedi E, Luzzi Graz, Edwards Anne, Rousseau Christine M, Rosseau Christine M, Mullins James I, Tudor-Williams Gareth, Novelli Vas, Brander Christian, Douek Daniel C, Kiepiela Photini, Walker Bruce D, Goulder Philip J R
Abstract excerpt
HLA diversity is seen as a major challenge to CTL vaccines against HIV. One current approach focuses on "promiscuous" epitopes, presented by multiple HLA alleles from within the same HLA supertype. However, the effectiveness of such supertype vaccines depends upon the functional equivalence of CTL targeting a particular epitope, irrespective of the restricting HLA. In this study, we describe the promiscuous...
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