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Article

Testing linkage and gene x environment interaction: comparison of different affected sib-pair methods.

Genetic epidemiology - 1 Jul 2003

Dizier M H, Selinger-Leneman H, Genin E

Abstract excerpt

The aim of this study was to compare, under different models of gene-environment (G x E) interaction, the power to detect linkage and G x E interaction of different tests using affected sib-pairs. Methods considered were: 1) the maximum likelihood lod-score (MLS), based on the distribution of parental alleles identical by descent (IBD) in affected sibs; 2) the sum of the MLS (sMLS) calculated in affected...

Topics

Environment
Genetic Linkage
Genetic Predisposition to Disease
Humans
Models, Genetic
Siblings

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12813728
DOI: 10.1002/gepi.10244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12813728-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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