Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

Abstract excerpt

The power to detect disease-susceptibility loci through linkage analysis using pairs of affected relatives and affected-unaffected pairs is examined. Allelic identity by descent (ibd) for a completely polymorphic marker for sibling, uncle-nephew, grandparent-grandchild, half-sib, and first-cousin pairs is considered. Affected-unaffected pairs generally represent a poor strategy. For single-locus models, ibd...

Topics

• Alleles
• Female
• Genetic Diseases, Inborn
• Genetic Linkage
• Genetics, Medical
• Humans
• Male
• Models, Genetic
• Models, Statistical
• Pedigree
• Probability
• Recombination, Genetic