Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci.

doi:10.1002/gepi.20077

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Article

Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci.

Genetic epidemiology - 1 Jul 2005

Howson Joanna M M, Barratt Bryan J, Todd John A, Cordell Heather J

Abstract excerpt

We compared different ascertainment schemes for genetic association analysis: affected sib-pairs (ASPs), case-parent trios, and unrelated cases and controls. We found, with empirical type 1 diabetes data at four known disease loci, that studies based on case-parent trios and on unmatched cases an...

Topics

Diabetes Mellitus, Type 1
Epistasis, Genetic
Family
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Humans
Models, Genetic
Population Groups
Risk

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