Article
A joint test of linkage and gene x environment interaction, with affected sib pairs.
Genetic epidemiology - 1 Jan 1999
Gauderman W J, Morrison J L, Siegmund K D, Thomas D C
Abstract excerpt
In the presence of gene x environment (G x E) interaction, the expected proportion of alleles shared identical by descent at a linked marker locus by a pair of affected sibs depends on the exposure profile of the two sibs, i.e., whether both are exposed to E, only one is exposed, or neither are exposed. In this paper, we propose an extension of the commonly used mean test of linkage to test for differential...
Topics
- Alleles
- Environment
- Genetic Linkage
- Genetic Markers
- Genetic Testing
- Genetic Variation
- Humans
- Models, Statistical
- Nuclear Family
- Reproducibility of Results