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Article

Sample size requirements for indirect association studies of gene-environment interactions (G x E).

Genetic epidemiology - 1 Apr 2008

Hein Rebecca, Beckmann Lars, Chang-Claude Jenny

Abstract excerpt

Association studies accounting for gene-environment interactions (G x E) may be useful for detecting genetic effects. Although current technology enables very dense marker spacing in genetic association studies, the true disease variants may not be genotyped. Thus, causal genes are searched for by indirect association using genetic markers in linkage disequilibrium (LD) with the true disease variants. Sample...

Topics

Algorithms
Case-Control Studies
Environment
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Humans
Linkage Disequilibrium
Models, Genetic
Sample Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18163529
DOI: 10.1002/gepi.20298

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