Comparison of statistics for candidate-gene association studies using cases and parents.

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Article

Comparison of statistics for candidate-gene association studies using cases and parents.

American journal of human genetics - 1 Aug 1994

Schaid D J, Sommer S S

Abstract excerpt

Studies of association between candidate genes and disease can be designed to use cases with disease, and in place of nonrelated controls, their parents. The advantage of this design is the elimination of spurious differences due to ethnic differences between cases and nonrelated controls. Howeve...

Topics

Alleles
Case-Control Studies
Chi-Square Distribution
Confounding Factors, Epidemiologic
Ethnicity
Gene Frequency
Genes, Dominant
Genes, Recessive
Genetic Diseases, Inborn
Genotype
Heterozygote
Homozygote
Humans
Likelihood Functions
Matched-Pair Analysis
Models, Genetic
Odds Ratio
Parents

Source

Open in PubMed Open full text

Identifiers

PMID: 8037216
PMCID: PMC1918347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8037216-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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