The power of two-locus affected sib-pair linkage analysis to detect interacting disease loci.

doi:10.1002/gepi.20254

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Article

The power of two-locus affected sib-pair linkage analysis to detect interacting disease loci.

Genetic epidemiology - 1 Jan 2008

Hallgrímsdóttir Ingileif B, Speed Terence P

Abstract excerpt

It has been shown that two-locus linkage analysis can, for some two-locus disease models, be used to detect effects at disease loci that do not reach significance in a genome scan. However, few examples exist where two-locus linkage has been successfully used to map genes. We study the possible g...

Topics

Alleles
Chromosome Mapping
Computer Simulation
Genetic Linkage
Humans
Models, Genetic
Nuclear Family
Siblings

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