Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis.

BMC genetics - 30 Dec 2005

Millstein Joshua, Siegmund Kimberly D, Conti David V, Gauderman W James

Abstract excerpt

Simulated Genetic Analysis Workshop 14 data were analyzed by jointly testing linkage and association and by accounting for epistasis using a candidate gene approach. Our group was unblinded to the "answers." The 48 single-nucleotide polymorphisms (SNPs) within the six disease loci were analyzed in addition to five SNPs from each of two non-disease-related loci. Affected sib-parent data was extracted from the...

Topics

Databases, Genetic
Epistasis, Genetic
Genetic Linkage
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Reproducibility of Results

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 16451607
DOI: 10.1186/1471-2156-6-S1-S147
PMCID: PMC1866788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16451607-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis.PMID 16451607Read ↗

Comparative analysis of methods for detecting interacting loci.Semantic proximity Read ↗

Detecting gene-gene interactions that underlie human diseases.Semantic proximity Read ↗

A joint test of linkage and gene x environment interaction, with affected sib pairs.Semantic proximity Read ↗

Detecting rare variant associations: methods for testing haplotypes and multiallelic genotypes.Semantic proximity Read ↗

Disease-driven detection of differential inherited SNP modules from SNP network.Semantic proximity Read ↗

Detecting susceptibility genes in case-control studies using set association.Semantic proximity Read ↗

Innate immunity genes as candidate genes: searching for relevant natural polymorphisms in databases and assessing family-based association of polymorphisms with human diseases.Semantic proximity Read ↗

Two-stage two-locus models in genome-wide association.Semantic proximity Read ↗

Strategies for detecting susceptibility genes in a complex disease.Semantic proximity Read ↗

Association testing strategy for data from dense marker panels.Semantic proximity Read ↗

Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases.Semantic proximity Read ↗

Testing association and linkage using affected-sib-parent study designs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.