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Article

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Six Emmanuelle, Ndiaye Delphine, Laabi Yacine, Brou Christel, Gupta-Rossi Neetu, Israel Alain, Logeat Frederique

Abstract excerpt

Notch signaling is involved in numerous cell fate decisions in invertebrates and vertebrates. The Notch receptor is a type I transmembrane (TM) protein that undergoes two proteolytic steps after ligand binding, first by an ADAM (a distintegrin and metalloprotease) in the extracellular region, followed by gamma-secretase-mediated cleavage inside the TM domain. We demonstrate here that the murine ligand Delta1...

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Identifiers

PMID: 12794186
DOI: 10.1073/pnas.1230693100
PMCID: PMC164639

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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