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Article

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

Nature - 22 Jun 2000

Huppert S S, Le A, Schroeter E H, Mumm J S, Saxena M T, Milner L A, Kopan R

Abstract excerpt

The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several steps of metazoan development. The mechanism by which extracellular signals affect gene transcription and ultimately cell fate decisions is beginning to emerge for the Notch signalling pathway. One paradigm is that ligand binding to Notch triggers a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10879540
DOI: 10.1038/35016111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.PMID 10879540Read ↗

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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase.Semantic proximity Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.Semantic proximity Read ↗

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.Semantic proximity Read ↗

Missing the notch in NOTCH1.Semantic proximity Read ↗

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.Semantic proximity Read ↗

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.Semantic proximity Read ↗

Proteolytic cleavage of Notch: "HIT and RUN".Semantic proximity Read ↗

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.Semantic proximity Read ↗

Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.Semantic proximity Read ↗

Jagged1 protein processing in the developing mammalian lensSemantic proximity Read ↗

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