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Article

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.

Neuroscience letters - 24 Jul 2006

Uemura Kengo, Kihara Takeshi, Kuzuya Akira, Okawa Katsuya, Nishimoto Takaaki, Ninomiya Haruaki, Sugimoto Hachiro, Kinoshita Ayae, Shimohama Shun

Abstract excerpt

N-cadherin is essential for excitatory synaptic contact in the hippocampus. At the sites of synaptic contact, it forms a complex with Presenilin 1(PS1) and beta-catenin. N-cadherin is cleaved by ADAM10 in response to NMDA receptor stimulation, producing a membrane fragment Ncad/CTF1 in neurons. NMDA receptor stimulation also enhances PS1/gamma-secretase-mediated cleavage of N-cadherin. To characterize the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16687212
DOI: 10.1016/j.neulet.2006.04.018

Genes

ADAM10
CTF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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