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Article

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.

The Journal of biological chemistry - 5 Jun 2015

Habets Roger A J, Groot Arjan J, Yahyanejad Sanaz, Tiyanont Kittichoat, Blacklow Stephen C, Vooijs Marc

Abstract excerpt

Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in the NOTCH1 NRR are associated with ligand-independent activation and frequently found in human T-cell malignancies....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25918160
DOI: 10.1074/jbc.M115.643676
PMCID: PMC4505536

Genes

NOTCH1
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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