Article
Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure
17 Sept 2010
Abstract excerpt
The "a disintegrin and metalloproteases" (ADAMs) are membrane-anchored metzincins of the adamalysin subfamily. This review gives an overview over the biological function and structure of ADAMs focusing on members of the family that display proteolytic activity. ADAMs are involved in a range of human diseases such as cancer metastasis, inflammatory disorders, neurological disease or asthma. It is, however, often...