Article
Processing of the notch ligand delta by the metalloprotease Kuzbanian.
Science (New York, N.Y.) - 1 Jan 1999
Qi H, Rand M D, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S
Abstract excerpt
Signaling by the Notch surface receptor controls cell fate determination in a broad spectrum of tissues. This signaling is triggered by the interaction of the Notch protein with what, so far, have been thought to be transmembrane ligands expressed on adjacent cells. Here biochemical and genetic analyses show that the ligand Delta is cleaved on the surface, releasing an extracellular fragment capable of binding to...
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