Article
Processing of the notch ligand delta by the metalloprotease Kuzbanian.
Science (New York, N.Y.) - 1 Jan 1999
Qi H, Rand M D, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S
Abstract excerpt
Signaling by the Notch surface receptor controls cell fate determination in a broad spectrum of tissues. This signaling is triggered by the interaction of the Notch protein with what, so far, have been thought to be transmembrane ligands expressed on adjacent cells. Here biochemical and genetic a...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cells, Cultured
- Disintegrins
- Drosophila
- Drosophila Proteins
- Female
- Intracellular Signaling Peptides and Proteins
- Ligands
- Male
- Membrane Proteins
- Metalloendopeptidases
- Molecular Sequence Data
- Mutation
- Neurons
- Protein Processing, Post-Translational
- Receptors, Notch