Article
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
PloS one - 29 Jun 2009
Rubio-Aliaga Isabel, Przemeck Gerhard K H, Fuchs Helmut, Gailus-Durner Valérie, Adler Thure, Hans Wolfgang, Horsch Marion, Rathkolb Birgit, Rozman Jan, Schrewe Anja, Wagner Sibylle, Hoelter Sabine M, Becker Lore, Klopstock Thomas, Wurst Wolfgang, Wolf Eckhard, Klingenspor Martin, Ivandic Boris T, Busch Dirk H, Beckers Johannes, Hrabé de Angelis Martin
Abstract excerpt
BACKGROUND: The Notch signaling pathway is an evolutionary conserved signal transduction pathway involved in embryonic patterning and regulation of cell fates during development and self-renewal. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, involving as well other signal transduction pathways, and implicated in distinct human diseases. Delta-like 1 (Dll1) is...
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