The Notch1 receptor is cleaved constitutively by a furin-like convertase.

doi:10.1073/pnas.95.14.8108

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Article

The Notch1 receptor is cleaved constitutively by a furin-like convertase.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998

Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah N G, Israël A

Abstract excerpt

The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that proteolytic processing of p300 is an essential step in the formation of the biologically active receptor because only th...

Topics

Calcimycin
Enzyme Inhibitors
Furin
HeLa Cells
Humans
Ionophores
Membrane Proteins
Mutation
Receptor, Notch1
Receptors, Cell Surface
Signal Transduction
Subtilisins
Transcription Factors

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