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Article

L1cam-mediated developmental processes of the nervous system are differentially regulated by proteolytic processing

6 Mar 2019

Abstract excerpt

Normal brain development depends on tight temporal and spatial regulation of connections between cells. Mutations in L1cam, a member of the immunoglobulin (Ig) superfamily that mediate cell-cell contacts through homo- and heterophilic interactions, are associated with several developmental abnormalities of the nervous system, including mental retardation, limb spasticity, hydrocephalus, and corpus callosum...

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PMID: 30842511
DOI: 10.1038/s41598-019-39884-x

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