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Article

Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.

Molecular and cellular biology - 1 Nov 2009

Bozkulak Esra Cagavi, Weinmaster Gerry

Abstract excerpt

Notch signaling requires a series of proteolytic cleavage events to release the Notch intracellular domain (NICD) that functions directly in signal transduction. The Notch receptor is locked down in a protease-resistant state by a negative regulatory region (NRR) that protects an ADAM (a disintegrin and metalloprotease) cleavage site. Engagement with ligand-bearing cells induces global conformational movements in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19704010
DOI: 10.1128/MCB.00406-09
PMCID: PMC2772745

Genes

ADAM10
ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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