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Article

Jagged1 protein processing in the developing mammalian lens

1 Jan 2019

Abstract excerpt

Notch signaling regulates a multitude of cellular processes. During ocular lens development this pathway is required for lens progenitor growth, differentiation, and maintenance of the transition zone. After ligand-receptor binding, the receptor proteins are processed, first by ADAM proteases, then by γ-secretase cleavage. This results in the release of a Notch intracellular domain (N-ICD), which is recruited...

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PMID: 30890522
DOI: 10.1242/bio.041095

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