Article
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jan 2000
Zhang Li-Fang, Gao Wei-Min, Gealy Robert, Weissfeld Joel, Elder Elaine, Whiteside Theresa L, Keohavong Phouthone
Abstract excerpt
Mutations in the K-ras gene are frequently found in lung tumours and are implicated in the development of lung cancer. In order to investigate the clinical usefulness of these mutations in lung cancer, we applied a sensitive method to compare mutations in codon 12 of the K-ras gene in DNA extracted from lung tumours and the matched sputum samples obtained from 22 lung cancer patients. K-ras mutations were...
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