Article
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
International journal of cancer - 22 Apr 1997
Keohavong P, Zhu D, Melacrinos A C, DeMichele M A, Weyant R J, Luketich J D, Testa J R, Fedder M, Siegfried J M
Abstract excerpt
Mutations in the K-ras gene are often identified in lung tumors and are implicated in the development of lung cancer. We used a sensitive method to analyze low-fraction mutations occurring in codon 12 of the K-ras gene in 114 primary lung tumors, including 77 adenocarcinomas, 31 squamous cell carcinomas and 6 adenosquamous carcinomas, which had previously been shown to be negative for codon 12 K-ras mutation in a...
Topics
- Adenocarcinoma
- Aged
- Carcinoma, Adenosquamous
- Carcinoma, Squamous Cell
- Codon
- Electrophoresis
- Female
- Genes, ras
- Humans
- Lung Neoplasms
- Male