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Article

K-ras mutations in non-small-cell lung carcinoma: a review.

Clinical lung cancer - 1 Jul 2006

Aviel-Ronen Sarit, Blackhall Fiona H, Shepherd Frances A, Tsao Ming-Sound

Abstract excerpt

The Ras proteins are pivotal regulators of cellular proliferation, differentiation, motility, and apoptosis. Mutations on the K-ras gene have been found in 20%-30% of non-small-cell lung cancers and are believed to play a key role in this malignancy. Herein, we review the complex biochemical mechanisms through which K-ras exerts its cellular effects and the results from studies designed to evaluate the clinical...

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Identifiers

PMID: 16870043
DOI: 10.3816/CLC.2006.n.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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