Analysis of Mutations in K-ras and p53 Genes in Sputum and Plasma Samples.

doi:10.1007/978-1-0716-0223-2_22

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Article

Analysis of Mutations in K-ras and p53 Genes in Sputum and Plasma Samples.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Zhang Lifang, Gao Weimin, Keohavong Phouthone

Abstract excerpt

Sputum and plasma can provide noninvasive materials to investigate biomarkers for cancer detection and diagnosis. Mutations in the K-ras oncogene and p53 suppressor gene have been frequently found in sputum and plasma samples collected not only from lung cancer patients but also in those of patients prior to presenting clinical symptoms of lung cancer, suggesting that they may also provide useful biomarkers from...

Topics

Circulating Tumor DNA
DNA Mutational Analysis
DNA, Neoplasm
Epithelial Cells
Genes, p53
Genes, ras
Humans
Lung Neoplasms
Mutation
Point Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Proto-Oncogene Proteins p21(ras)
Sputum
Workflow

Source

Open in PubMed

Identifiers

PMID: 31989568
DOI: 10.1007/978-1-0716-0223-2_22

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